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KMID : 1134120130160020171
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Journal of Breast Cancer
2013 Volume.16 No. 2 p.171 ~ p.177
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Sunlight Exposure and Breast Density: A Population-Based Study
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Wu Sheng-Hui
Ho Suzanne C.
So Edwin
Ku Susanna
Lam Tsz-ping
Qin Ling
Woo Jean
Yuen PY
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Abstract
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Purpose: This study aims to assess the association of sunlight exposure with breast cancer risk, measured by the breast density assessed from Tabar’s mammographic pattern in Chinese women.
Methods: A total of 676 premenopausal women were recruited to participate in this study, in which 650 completed a validated sunlight exposure questionnaire via telephone. The mammograms were classified according to Tabar’s classification for parenchyma, and patterns IV & V and I, II & III indicated respectively high and low risk mammographic patterns for breast cancer. The odds ratios (OR) and 95% confidence intervals (CIs) for sun exposure-related variables were estimated using unconditional logistic regression with adjustment for potential confounders.
Results: Among 646 participants, women with high breast cancer risk (Tabar’s patterns IV &V) had less hours spent in the sun than those with low risk (I, II & III) at any age stage. A higher level of sunlight exposure was associated with a significantly lower risk having high risk Tabar’s pattern. Women aged 40 to 44 years who were in the highest tertile of lifetime total hours spent in the sun had a multi-adjusted OR of 0.41 (95% CI, 0.18-0.92; p for trend=0.03) compared with those in the lowest tertile (>2.19 hr/day vs. <1.32 hr/day). For hours spent in the sun across the ages of 6 to 12 years, the comparable OR was 0.37 (95% CI, 0.15-0.91; p for trend=0.03).
Conclusion: These findings suggest that higher sunlight exposure is related to a lower risk of having high risk breast density pattern in premenopausal women. Our results also suggest the most relevant period of exposure is during earlier life.
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KEYWORD
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Breast neoplasms, Mammographic density, Sunlight, Vitamin D
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